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Furthermore, for future studies, we recommend to include more than two different dilution steps for the titrated nasal challenge test to obtain more differentiated effects.
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Such a measure would be of high relevance for the health sector as well, since it would allow a more differentiated assessment of the effects of WTO agreements than the dummy variable approach applied in this study.
Our model describing one of these physiological ROS effects can account for a more differentiated understanding of real ROS effects on ageing.
In contrast, L. gasseri had relatively little effect on the more differentiated HT29‐MTX sub‐clone: here the specific effect of EPA was apparent both in the presence and absence of L. gasseri.
In an open letter to the Federal President of Germany, the lead authors of the review [ 3], supported by 40 German scientists and agricultural economists, have called for a more differentiated discussion about the potential effects of financial speculations and actively advocated against the regulation of agricultural markets.
When there is a low or environmental dose impregnation of the feed (with a pesticide GM plant for instance), the chronic effects could be more differentiated according to the sex, the physiological status, the age, or the number of intakes over such and such a period of time in the case of a drug.
Moreover, the combined treatment has an important effect also on more differentiated cancer cells, suggesting that this combination may target different cancer cell populations.
Cells of the A549-NT subpopulation retains the characteristics of a more differentiated, contact-inhibited cell type without tumorigenic effects in the nude mouse system, whereas A549-T cells exhibit a relatively undifferentiated, anchorage-independent cell growth.
It is becoming evident that, in addition to intrinsic resistance mechanisms, complex cytokine networks within the tumor microenvironment can rescue and promote CSC activity while more differentiated cells within the tumor succumb to the effects of conventional therapies.
This construct effectively counteracted the effect of RNAi and showed a more differentiated phenotype than in the PC12-RNAi cells (Supplementary Figure 4).
This effect was not limited to more differentiated cells, but was also detected in immature CD34+38− cells (Figure 3A).
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