However, there are also data indicating that cancers may arise from more differentiated cells that undergo de-differentiation (Torres-Montaner, 2011).
At the same time, stem cells need to generate more differentiated cells that ultimately undergo terminal differentiation.
Stem cells can also be distinguished from more differentiated cells.
However, wider application of this methodological approach to more differentiated cells such as neurons would also be useful for the screening of compounds that modulate synaptic transmission.
Among this group of patients, Michor concluded, imatinib did not eliminate the cancer stem cells: Instead, it targeted more differentiated cells, such as progenitor cells.
This may be due to the presence of more differentiated cells in the transplant population, of which 16% express DCX.
If these cells represent TICs, the majority of the bulk sphere cells are more differentiated cells [12].
This effect was not limited to more differentiated cells, but was also detected in immature CD34+38− cells (Figure 3A).
Different activity of cellular restriction factors like APOBEC proteins [8] [10] may contribute to the different susceptibility of monocytes and more differentiated cells to HIV-1.
It is possible that the more differentiated cells of the marrow, i.e. myelomonocytes (which are neutrophil equivalents) have lower telomerase activity and bring down the total level [21].
Neurospheres are free-floating heterogeneous aggregates that contain a minority of neural stem cells together with various progenitors and more differentiated cells.
