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Interestingly, rates of current smoking were more differentiated by SES at the later date, following differential changes in smoking rates between 1990 and 2003 by SES.
In Romania, such ownership is quite recent, and more differentiated by class than in the United States and Western Europe [ 1, 23].
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Tertiary institutions were reconceived as part of a unified level, testing became more sophisticated, and credentials became more differentiated either by certificate or by transcript.
Genetic profiles observed in this work showed some similarities between RS and SM samples, but epigenetic profiles were more differentiated as shown by PCAs (Figure 2) and differentiation indices (Table 3).
Populations of glial progenitors (GPs) which are capable of generating both astrocytes and oligodendrocytes were distinguished from neural progenitor cultures by their expression of PDGFRα and Olig1, and distinguished from more differentiated OP cells by their lack of expression of O1 and O4.
In this system, both EC types grew vigorously for more than a week and became increasingly more differentiated, as shown by multiplexed gene expression.
Taking these findings together, it seems likely that Hox-C9 promotes a more differentiated neuroblastoma phenotype by the downregulation of REST.
These cells were more differentiated (as assessed by ALP activity, Fig. 5B) and had significantly increased apoptotic potential (Fig. 5C) compared with the Caco2-15EMP cells.
Consistent with this finding, increased NEU4 activity and expression induced in the more differentiated GBM cells by the NEU4 agonist thymoquinone increased the expression of OCT-4 and GLI-1.
Moreover, as CSCs may be generated from more differentiated tumor cells by phenotype switching, therapies employing drugs that specifically target CSCs in combination with drugs with toxicity toward bulk cancer cell populations might be a highly effective strategy for eradicating melanoma tumors.
Significantly, after NEU4 silencing, GD3 synthase expression was reduced to the level shown by more differentiated U87MG cells.
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