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However, other categories show more differential regulation.
The up regulation of proliferation markers in both adjacent normals and tumors coupled with the result that more differential regulation is detected when tumors are compared to donors than to adjacent normals suggests that donor prostates may be the more appropriate tissue for expression studies.
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A higher J score represents a more significant differential regulation.
If so, more elaborate differential regulation of quorum-sensing targets than we have shown here could occur in response to environmental changes.
Consequently, HCPs and ICPs are more prone to differential regulation by DNA methylation than are LCPs [ 42].
As we continued to investigate other targets of miR-205, we found more examples of differential regulation in the androgen-dependent and -independent cell lines.
Conversely, very different motif compositions would be more consistent with differential regulation in which a distal regulatory element could interact with only one or a subset of the promoters.
The function of these two actins is likely more related to their differential regulation in space and time than to their protein coding information [ 49].
Therefore, untargeted algorithms are capable of detecting DC in more general situations where differential regulation neither occurs within predefined external nor internal modules.
As is mentioned above, differential coexpression analysis (DCEA) is more powerful in unveiling differential regulation mechanisms of diseases than differential expression analysis (DEA) since differential regulations would display as the decoupling of expression correlation [ 22, 24].
These results indicate that the general topology of the networks is more conserved than is differential regulation of the individual proteins in each dataset, supporting our notion that network topology provides information not provided by differential regulation in some cases.
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