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Some genes are represented by two or more different array elements.
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We cross-validated gene array by the mean of correlation index of 12 genes present in two or more different arrays (signal transduction vs apoptosis: r = 0.956; apoptosis vs DNA-damage: r = 0.986; signal transduction vs DNA-damage: r = 0.999).
To obviate fundamental difference inherent in different array platforms, we focused mainly on gene expression data based on Affymetrix oligonucleotide arrays, particularly more advanced platforms such as U95Av2 or U133 series.
To construct a different array, one or more of these projections must change.
Expression values were excluded unless the values for at least 20% of the arrays were 1.5-fold or more different from the median for that probe set.
A miRNA family was included in the analysis if two or more family members appeared in at least two of the three different array comparisons.
In order to minimise possible bias caused by different array resolutions used in the different studies, we analysed these differences for CNVs >100 kb (as these are more likely to be detected by all arrays).
More systematic approaches have been proposed for integration of findings from multiple studies using different array technologies.
The present study focuses on comparison of different array platforms and therefore the results of the biological function will be discussed more extensively elsewhere (Schenk in preparation).
"Everybody has different skills and they have different personalities and a different array of experiences".
Two different array formats were used for different aims.
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