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Data were then organised using a categorisation matrix (see Methods section for more details) developed by the research team.
When it became feasible to map rough terrain in more detail, hachuring developed into an artistic speciality.
To analyze the cellular expression of Jmjd6 in more detail, we developed several Jmjd6 deletion constructs, which were fused C-terminal to yellow fluorescent protein (YFP) (Figure 4).
In order to characterize the interaction between CaM and STIM1 and STIM2 in more detail, we developed a fluorescence-based in vitro CaM-binding assay.
To examine this issue in more detail, we developed a new duplication-divergence model named the degree-dependent duplication (DDD) model by modifying the NHD model that we proposed previously [ 14].
To study these patterns in more detail, we developed an algorithm to identify tissue-specific differentially methylated regions systematically using 450k methylation data as described in Figure 1 (also see Methods).
To explore the chromocenter phenotype in more detail, we developed a statistic, referred to as an aggregation index (AI) (see Methods), to characterize the distribution of visible DAPI-bright spots within interphase nuclei.
In order to study this mechanism in more detail, we developed a human surrogate model system based on cytokine activation of peripheral blood lymphocytes, and found that after 8 days these cytokine-activated T cells (but not those activated by crosslinked anti-CD3) mimicked the effector function of rheumatoid T cells [ 17, 25].
We will discuss these points in more detail when we develop the model formally.
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