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Solving the simplified networks gives information used to remove options from the more detailed network representations.
The resulting network allows for network-resolution adjustment based on available data and provides a starting point for further, more detailed, network reengineering with less computational complexity.
The meso-scale network topology may provide a starting point for further, more detailed network reengineering algorithms helping to improve their computational performance.
Since the model is based on direct pattern identification within a network, it provides an efficient method to identify functional interaction or crosstalk between stimulation pathways (also referred to as 'structures') which can be used to define constraints for more detailed network reconstruction.
Direct Model II (Fig. 1D) which is a more detailed network involving Bax auto-activation also shows bistability (Fig. 3).
In 2006, Bansal et al. [32] adopted a more detailed network model with which they also evaluated these strategies, obtaining results qualitatively similar to ours.
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The current challenges are to figure out more detailed networks involving all the molecular elements (metabolite, protein, and transcript) in a global manner across a variety of biological conditions.
Network sparsity in turn can be separated into two more detailed measures: network in-degree distribution, derived from the distribution of regulatory edges entering each target gene, and network out-degree distribution, derived from the distribution of regulatory edges leaving each regulator.
For example, [ 17, 18] describe methodologies for extracting influence networks from more detailed reaction networks, and [ 19] systematically explores the kinetics of small influence networks.
The reason might be that a lower stream threshold value led to a much more detailed stream network with more second-order and third-order streams in Simulation C. The detailed stream network resulted in a long network length, a large number of streams, and a large number of catchments.
The role of transcriptional networks in determining mode of action of small molecules is undoubtebly growing, thanks to availability of more detailed gene network models and to the ever increasing amount and quality of GEPs.
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