Using Ingenuity Pathway Analysis System and pathway designer (IPA 8.5, Ingenuity Systems, Edwood, CA, USA), we performed more detailed functional analysis to identify miRNA-mediated, cancer-related and statistically significant networks, biological functions and canonical signaling pathways for both differentially expressed miRNAs and mRNAs.
The renewed interest in the effect of dietary interventions on acne, the elucidation of the involvement of TLR and MMPs in acne pathogenesis, and a more detailed functional understanding of various treatment modalities at the molecular level are all promising indications that advances in therapeutics are sure to follow.
Figure 3 shows a more detailed functional diagram of the proposed system [14].
Meanwhile, the IMD method is able to provide more detailed functional MR images, which is very important in fMRI techniques (e.g. activity pattern detection).
First of all, we confirm that the MRN size distribution reproduces the observed extinction curve (some small deviations can be fitted further if we adopt a more detailed functional form of the grain size distribution, which is beyond the scope of this paper; see Weingartner and Draine, 2001, for a detailed fitting).
A more detailed functional analysis of the single consensus sequence YTAR is given in Figure 5.
Table S1 offers a more detailed functional characterization of these pathways, including the type of gene expression change observed in relation to VD+ samples.
In the future, a more detailed functional analysis of genes with altered expression in cancer will provide a better understanding of their role in this dynamic process.
The marine iguana sequence possesses several hallmarks of a nonclassical locus and can serve as the basis for more detailed functional studies of class I genes in this group.
The FBUA annotates GO terms to the lowest levels possible (i.e. GO leaves), and therefore can provide more detailed functional information than the annotation using the fixed level of GO terms, as what most studies did [15].
The advantage of FBUA is that it can provide much more detailed functional annotation than many "use-as-it-is" approaches where the original GO annotation is used regardless of the resolution.
