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Though BLES03 shares a higher degree of overall structural similarity with eIF4E, a more detailed active site comparison involving docking and MD simulations suggests BLES03 to be functionally analogous to PTLs (supplementary fig. S2 in supplementary file S2, Supplementary Material online).
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The study becomes more and more detailed, pro-active and conscious of the state of needing corrections, substantial improvements and experimental developments.
The results provide a more detailed understanding of active structures compared to previous studies [2, 13].
For example, pharmacy based measures may provide more detailed information on active chronic conditions for which patients are actually receiving care and not only serious conditions that diagnostic based measures may identify.
As for Alexa functionality, users can now ask the assistant for more detailed fitness information, including active minutes, calories, sleep and steps.
We have therefore included much more detailed descriptions of the active site events for the non-compartmental and especially for the compartmentalized models in the main text.
Preliminary studies on test clusters of proteins derived from PROSITE motifs using a simple entropy-based scoring function demonstrate that this approach is able to detect the fundamental molecular function shared by the members of the cluster (i.e. the PROSITE motif) in addition to more detailed information, such as active site residues (see Table 2).
More detailed in situ investigations of active structures would be required to decide which of the nodal planes the actual fault plane is.
More detailed investigation showed that this active period appeared to be a Steady Magnetic Convection event modulated by solar wind driving, and it is the topic of a subsection below.
A more detailed redox characterization of the active site states of Hyd-1 under N2 (Supporting Information, Figure S3) shows that these changes are fully reversible with potential.
A more detailed inspection of sections with active NMO lesions, however, revealed that at least six different lesion types were present, suggesting different type- and stage-specific patterns of tissue injury (Table 3).
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