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Although, there was no statistical differences between mock and CFTR knockdown cells in term of n-6 FA concentrations, CFTR-depleted cells displayed a lower delta-6 desaturase index suggesting impaired conversion of 18∶2, n-6 to more desaturated products.
The amount of desaturation in phospholipids unique to Cx32 hemichannels was more evenly distributed, and phospholipids with longer chain lengths were more desaturated.
The total carbon content of the acyl chains ranged from 30 to 38 (median 36), with the longer chains being more desaturated (Table 7).
The best fitting model (Fig. 4) for the 992 color pairs showed that more harmonious pairs were more similar in hue, cooler, more desaturated, and more similar in coolness (67.3% of the variance explained).
However, phospholipids unique to Cx26 plaques tended to be more desaturated than those in Cx32 plaques.
Similar(55)
In the ER, FAs may be elongated and more highly desaturated before they are incorporated into TAGs and PLs [ 16- 18].
Eighty-nine percent of participants with IPF desaturated more on the 6MWT than on the CPET (mean difference 3.4%, p < 0.001).
However, 37 participants (79%) desaturated more during the 6MWT than in the CPET (mean difference between tests 2.8%, p < 0.001).
In general, hairy root line HR E1.5 accumulated more n-3 desaturated FAs, and less saturated ones, reflected by the PC1 component (Additional file 2, Figure S3).
Although there is not a hard desaturation threshold established, athletes who desaturate more than others will likely be more negatively affected at altitude.
If patients felt unable to cycle for five minutes (symptom limited) or suffered significant desaturation (stopped by supervising physiotherapist if they desaturated by more than 4% from baseline and to less than 88%) whilst cycling they went on to try NIV assisted exercise.
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