To fully exploit LD in the Atlantic salmon genome, however, more dense maps would probably be needed.
Since 2001, the use of more and more dense maps has made researchers aware that combining linkage and linkage disequilibrium enhances the feasibility of fine-mapping genes of interest.
We believe that there would be diminishing returns from a more dense linkage map than the current, 0.2 cM dense linkage map 7386-markerr map), since we would not expect further QTL resolution and predictive accuracy from more markers, while the collinearity issues and computational burden would continue to increase [ 30].
The construction of a more dense linkage map around the ms1 gene will greatly facilitate its isolation or that of more tightly-linked markers.
As the mean number of voids goes to zero, the ratio (σ s 2 (r ) / S - 2 (r ) ) increases in (3), with the consequence that scaffolds with sparse pore distribution will have higher LAC than scaffolds with more dense pore maps, for the same r.
However, the availability to both larger sample sizes, more dense marker map [ 7, 8] and with application of new methodologies enforced by the venture from the Psychiatric Genomic Consortium (PGC) [ 9] have finally allowed for statistical robust signals from the CACNA1C, CACNB2, ODZ4, SYNE1 and NCAN genes.
This is only slightly more dense than the maps without these SNPs [ 5], which contained 3755 markers in 2306 positions covering 3013 cM on autosomes (1.3 cM spacing).
More dense alfalfa linkage maps and the forthcoming alfalfa whole-genome sequence could provide further clarification of the presence of this inversion between the two Medicago species.
Therefore an effort has been made in the present study to integrate the available information from the intraspecific maps in order to construct a more dense and saturated linkage map of chickpea.
A more dense or higher resolution map with additional EST-based markers would give a much better picture of the possible syntenic relationships between the genome of pearl millet and those of other sequenced species.
