For MI patients with diabetes, poorer self-care might be more deleterious compared with MI patients without diabetes because of the many and often complex self-care activities involved in diabetes management.
The missense alterations found in patients with more severe growth phenotypes are likely to be more deleterious alleles, with stronger possible effects on the GALNS enzyme (Supp. Table S4).
There is a burgeoning literature examining this association, and current evidence suggests that some atypical agents (e.g. clozapine and olanzapine) may have a more deleterious profile with regard to metabolic dysfunction than others (e.g. quetiapine and risperidone) [ 8, 9, 13].
Since the score is a reflection of how likely the variant is deleterious, it is by no means appropriate to consider a variant with a lower score as more deleterious than that with a higher score.
Aggressive BP lowering may be even more deleterious in elderly patients with isolated systolic hypertension.
68 Women with T2D are more likely than men to have hypertension, 134, 135 with more deleterious effects on cardiovascular health.
Indeed, complexes and pathways are thought to perform better with balanced concentrations of their members, and the duplication of a given gene is expected to disrupt the dosage balance of the interactions in which its encoded product is involved (Birchler et al. 2001; Veitia 2002; Papp et al. 2003), which may have more deleterious effects for proteins with a higher number of interactors.
Indeed, the duplication of a given gene is expected to disrupt the dosage balance of the interactions in which it is involved (Birchler et al. 2001; Veitia 2002; Papp et al. 2003), which may have more deleterious effects for genes with a higher number of interactors.
This study reveals that being diagnosed with dyslipidaemia could be more deleterious to YQOL than being diagnosed with hypertension.
A common assumption in the disease genetics literature is that disease manifestation statistically associates with decreased fitness, and therefore, that (i) disease susceptibility alleles are deleterious and (ii) alleles with more severe effects on disease susceptibility tend to be more deleterious to fitness than those with mild effects (Eyre-Walker 2010; Simons et al. 2013).
