Sentence examples for more deleterious mutations from inspiring English sources

It seems unlikely that a sexually reproducing parasitic plant would gain enough advantage from increased mutation rate, in terms of evading host defence, for selection on mutator alleles to outweigh the costs of producing more deleterious mutations.

If the SSM is correct, individuals who become schizophrenic patients will tend, on average, to have lower genetic fitness (e.g., more deleterious mutations) and poorer developmental conditions (e.g., nutritional deficiencies, infections, and so on) compared with those who do not.

Consequently, transformation on average is expected to introduce more deleterious mutations than it would remove.

It is hypothesized that these organisms have accumulated more deleterious mutations compared to non-endosymbionts.

As expected, the small population size lines had lower fitness because they had accumulated more deleterious mutations.

Specifically, when a mutation had a large effect on the standard deviation, more deleterious mutations could have greater detection power than less deleterious mutations under some conditions.

This particular mutation does not in itself cause polyposis or cancer, but instead is a true cancer predisposition gene, because it creates an instability in the colon cell's APC gene (making it hypermutable) that then may develop a more deleterious mutation that can lead to cancer.

While it is well established that more strongly deleterious mutations exhibit evolutionary profiles that differ from more neutral forms of variation in the human genome, it has been challenging to assess how much of a role natural selection has played in weakly deleterious mutations [10].

Further, since five of the six slowest evolving helices reside in MSD 1, mutations in this membrane spanning domain appear to be more deleterious than mutations in MSD 2. We then enhanced the analysis by considering the specific amino acids involved, including those inferred at individual sites throughout the evolutionary history of the CFTR family.

Numbering about 480 today, Virunga mountain gorillas have more potentially deleterious mutations than other gorillas, Scally says.

Small populations are thought to be adaptively handicapped, not only because they suffer more from deleterious mutations but also because they have limited access to new beneficial mutations, particularly those conferring large benefits.