Note that, in CDD and SDM, for low to moderate values (0.0-0.7 0.0-0.7lation at either end results in a similar BER degradation, however, for large values (>0.7), correlation at theithersmittendis significantly moresultsterinus than at the receiver.
Lower performance by saline genotypes in non-saline conditions could be due to more deleterious alleles at high frequency in saline populations and/or to the presence of locally adapted alleles that improve fitness in saline habitats but decrease fitness in non-saline habitats.
In contrast, HR recruitment might lead to more deleterious chromosomal rearrangements at collapsed replication forks (Iraqui et al. 2012; Mizuno et al. 2013).
Overall, most of the median substitution scores for the residues making hydrogen bonds (NH/CO/SC) are smaller or equal to those from non-hydrogen bonding residues (nh/co/sc), which implies it would be more deleterious if variants were to occur at amino acids making hydrogen bonds.
Our results suggest that neuroinflammation and/or oligodendrocyte dysfunction are more deleterious for axonal health than demyelination per se, at least in the short term.
However, at 500 μM, lead had a much more deleterious effect on mitochondrial function and subsequently induced excessive cell death; therefore this concentration was classified as toxic.
BACKGROUND: Heavy drinking in early adulthood among Blacks, but not Whites, has been found to be associated with more deleterious health outcomes, lower labor market success and lower educational attainment at mid-life.
The ≡Si-O-Si≡ linkage is very susceptible to hydrolysis at pH<3 and >8, with basic conditions significantly more deleterious than acidic conditions.
Genes in GOMF groups at the extreme left of Figure 1a have lower tolerance to perturbing nsSNVs (they have, on average, lower mean MA scores) than those at the extreme right, which tend to bear more deleterious nsSNVs.
Additional evidence for deletions being more deleterious than insertions is provided by their sample frequency distributions: polymorphic deletions segregate at significantly lower frequencies than polymorphic insertions (Table 2 and 3).
