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Some of them are labeled as fast triptans and share similar characteristics with sumatriptan, the prototype triptan, displaying a rapid dose-dependent efficacy, with a higher risk of adverse effects, while others seem to have a more delayed onset of the relieving effect on migraine symptoms, but a more prolonged duration of action and a reduced rate of recurrent migraine attacks [5].
Female mice display a more delayed onset RTT-like phenotype and were given an equivalent tamoxifen treatment regimen at 18 months of age (3 weekly followed a 4 daily injections) before being culled at 20 months.
The pathology caused by cardiotoxins and PLA2 myotoxins develops rapidly and it is associated with marked damage to the sarcolemma, whereas pathology associated with 'small' myotoxins has a more delayed onset and sarcolemma damage is not apparent.
Preprandial regular insulin, which has a more delayed onset, lower peak concentration, and longer duration of action compared with ultra-short-acting insulin (15, 16), may better match the absorption profile of low glycemic index foods.
It is possible that the effect of background vascular risk factors will be more visible when studying their long-term effects on more delayed onset of post-stroke dementia, occurring after 3 months and much further beyond.
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Female Mecp2+/stop mice are a gender appropriate and accurate genetic model of RTT yet show more subtle and delayed onset (4 12 months) neurological features [26] compared to hemizygous male mice.
Under this syndromic classification, any mushroom poisoning case is first stratified into three different presentation timings - early onset (less than 6 h), late onset (6-24 h), and delayed onset (more than 1 day).
People who exercise are healthier, more energetic, think more clearly, sleep better, have delayed onset of dementia...the list goes on.
FTD GRN- disease seemed more benign fbecause of the delayed onset and the persistence of the language.
This may be of concern, considering that post-disaster psychopathology, such as PTSD, may have a delayed onset of more than six months [ 24].
Whilst the pathology is similar when CIA is induced with either autologous or heterologous CII, the nature of the disease differs; autologous CII induces a more chronic disease with a delayed onset and reduced penetrance [ 84, 85].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com