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So the answer is a qualified yes, until we have more definitive trials.
Nevertheless, the theory of TCM coupled with laboratory studies and safety information can serve as a basis for the design of more definitive trials of TCM for specific indications in breast cancer.
Therefore, it is justified to conduct more definitive trials focusing on (disc) cartilage morphology, to unambiguously prove or disprove the beneficial affects of these supplements.
However, there is a need for completion and analysis of larger more definitive trials, including those with denosumab, to ensure the safety of this strategy.
Establishing such links will require evidence from experimental studies, and obtaining more definitive evidence of this kind will require exploratory trials upon which more definitive trials are based [ 14].
The efficacy of approaches such as physical activity, strength and cognitive training for improving brain health has not been established [ 4]; however, results from small, short-term trials are encouraging and support the larger, more definitive trials necessary to establish efficacy and prevention guidelines [ 5- 16].
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Pfizer, which sponsored the study, has started a more definitive trial aimed at winning approval of the drug, crizotinib.
These results might be used to calculate a necessary sample size in a larger more definitive trial.
As appropriate, ACRIN conducts small, rapid pilot trials of emerging technologies to determine whether a technology is ready for a more definitive trial and to gain insight as to what are the appropriate goals for such a trial.
Second, in accordance with pilot study guidelines [ 24], and given that our trial did not include an intervention, we established more stringent FC to reflect the factors that could hinder a larger, more definitive trial.
40 First of all, if a larger more definitive trial has to be conducted then a more realistic estimate of the recruitment rate will be needed and more centres should be involved.
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