Another limitation of this study is the reduced sample size; a larger sample could facilitate the generalization of the results to the Spanish population, as it would permit using more sophisticated statistical methods which provide greater statistical power and to achieve more definitive conclusions.
In addition, an important limitation of most of these studies is the small sample size used [ 57], which decreases statistical power and limits more definitive conclusions.
First, the small sample size in this pilot study may have reduced statistical power and the ability to make more definitive conclusions.
Hence in an aim to overcome this pooling the results of clinical studies into a meta-analyses with a statistical calculus has been assumed to be a more definitive way of deciding of efficacy.
We simply don't have the quality of data, and statistical analysis of that data, to say anything much more definitive than that.
Then, because of the limits of RCTs in the case of adverse events such as ischemic events, we believed that observational studies with newer statistical causal models would be less biased and could lead to more definitive conclusions about the deleterious effect of transfusion in different subgroups and for different outcomes.
By avoiding the bias inherent in those studies employing manual ROIs and allowing the application of a statistical procedure, by depicting regional brain differences with good spatial resolution and by affording more definitive conclusions than single VBM studies, ALE is considered the most sophisticated and best-validated method of coordinate-based voxel-wise meta-analysis [ 61, 62].
Our results affirm the value of a future, more definitive trial of TC for osteopenic women, provide the preliminary required data for determining sample size for appropriate statistical power for such a trial, and contribute to a growing literature evaluating TC for bone health and fall-related fracture risk.
He added that it's hard to get a definitive statistical picture of plots and acts of violent extremism since that definition tends to vary and data for incidents nationwide is hard to come by.
Differences in mRNA levels, however, did not reach statistical significance, but this lack of association could be related to our small sample size, precluding a more definitive interpretation of our findings.
