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20 More high quality randomised controlled trials are needed to evaluate the effectiveness of additional supervised exercises in more defined subgroups such as athletes and patients with severe injuries.
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Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients.
The size of our study population was sufficient only to detect significant risk factors associated with an OR ≥ 2 in the two veteran subgroups evaluated and did not allow us to evaluate more precisely defined subgroups.
The small number of participants in the final RECursive Partitioning and AMalgamation (RECPAM) analysis, together with the wide SDs, raises the possibility that a larger sample may improve the performance of the frontal assessment battery in more clinically defined subgroups.
Further trials including more patients and defined subgroups are needed before recommendations for the use of heparin in neutropenic sepsis can be made (CI).
People who could be unambiguously allocated to the defined subgroups had slightly more severe symptoms and more disability than those who could not be allocated.
The nature of the electronic data sets available means it is not possible to obtain other factors contributing to cardiovascular and diabetes risks to more precisely define subgroups and allow a direct comparison of the cohorts' baseline levels of risk of developing diabetes (eg, body mass index and family history).
More research, with larger numbers of patients, and in defined subgroups, should be carried out to address these issues.
Improved ability to implement targeted interventions for readily defined subgroups of the intended population may result in more efficient and effective use of resources.
More research is needed on assessing efficacy of potential therapies within histologically defined subgroups.
As illustrated on Figure S1 (Additional File 2), for more than 75% of the tumours, the correlation was the highest with the expression profile of the subgroup containing that sample, stressing the relevance of the defined subgroups.
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