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TritonX-100 modified ZnO NPs, owing to its smaller size, should have instigated more cytotoxic effect [19] but a contradictory result was observed.
Interestingly, AVO-b showed 10-15% more cytotoxic effect than AVO-l in all the tested doses and time points.
Conjugate with less molar ratio SN38-HSA-15 SN38-HSA-15 SN38-HSA-15 cytotoxic evoked than the SN38-HSA-60.
In addition, the GSTT1 null genotype conferred a 2.8-fold reduction in risk of relapse in childhood acute lymphoblastic leukemia indicating a more cytotoxic effect of chemotherapy [ 16].
The soft tissue sarcoma BN-175 used in this study was found to be susceptible to actinomycin D, but addition of TNF did not result in a more cytotoxic effect on these tumour cells.
Similar(55)
Surprisingly, and in contrast to the observations made on OS cell lines, combination treatment of Ad5-Δ24RGD with doxorubicin or cisplatin did in most cases not result in a more pronounced cytotoxic effect compared to the most effective single agent treatment.
In addition, the data obtained suggest that the methanolic extract of Phyllanthus seemed to have more pronounced cytotoxic effect than aqueous extract, indicating the methanol-soluble bioactive compounds contained in Phyllanthus are probably more potent than the aqueous-soluble bioactive compounds in killing cancer cells.
Thus, our data suggest that the more prominent cytotoxic effect of phenothiazines in SCLC is related to a higher degree of lysosomal pH neutralization (ΔLysoTracker) that is more persistent in SCLC than in NSCLC.
Furthermore, at 70.0 µM compound 4 induced a more pronounced cytotoxic effect than Vorinostat (68.6% vs 56.6% of dead cells) in MCF7 cancer cell line.
Most of the compounds inhibited EGFR kinase wild type (EGFR WT) with IC50 values in the low nanomolar range (<0.495 9.05 nM) and displayed more potent cytotoxic effect in BaF/3 expressing EGFR WT than reference compound gefitinib.
Thus, is the observed PB disruption a consequence of a more general cytotoxic effect?
Related(20)
more humorous effect
more surprising effect
more refined effect
more devastating effect
more poisonous effect
more shattering effect
more sinister effect
more profound effect
more lasting effect
more complicated effect
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more direct effect
more decisive effect
more valuable effect
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more limited effect
more cytotoxic activity
more subtle effect
more cytotoxic quinone
more pronounced effect
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Justyna Jupowicz-Kozak
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