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We thank the reviewers/editors for the suggestion of showing more crystallographic evidences.
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As more crystallographic data becomes available, the success of these models can be more directly assessed.
Crystallographic evidence of binding mode and in vivo potency data is also highlighted.
The data presented support the proposed theory with microstructural and crystallographic evidence.
Does the crystallographic evidence convince that the guest is best described as 1,3-dimethylcyclobutadiene in close proximity to a detached molecule of carbon dioxide? 3.
This is illustrated by crystallographic evidence that show the macrocycles can host guests (such as CH2Cl2) or can fold and form unexpected Cu(I) dtc clusters.
Site directed mutagenesis and crystallographic evidence has proved the essentiality of these residues for enzyme activity.
In conjunction with crystallographic evidence, this suggests that the B site is occupied in the absence of substrate.
Weber and colleagues showed crystallographic evidence of M61 rotated toward solvent, where M61 occupies the position of H121 if it were H-bonded to T62.
In another study [ 65], crystallographic evidence revealed the flexible nature of an extended intermodular linker of an A. cellulolyticus scaffoldin subunit.
α-Mannosidases of families GH38, 47 and 92 are metal dependent, with crystallographic evidence for the divalent metal cation (Zn2+ or Ca2+) binding O2 and O3.
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