Sentence examples for more critical functions from inspiring English sources

The smaller is this ratio means more critical functions the gene plays in the organisms.

ATN-1 protein is a potent transcriptional regulator, and in the more complex human central nervous system, ATN-1 may have more critical functions.

Renewed cooperation between Italy and Libya served another, more critical function: reducing the flow of illegal immigrants to Italy.

Therefore, we conclude that redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis, but that Nkx2.7 plays a more critical function, specifically indicated by the gain-of-function and loss-of- function experiments where Nkx2.7 is observed to regulate the expressions of tbx5 and tbx20 through the maturation stage.

In this study, we clearly demonstrate that, while Nkx2.5 and Nkx2.7 play redundant roles in the differentiation of cardiomyocytes, Nkx2.7 has a more critical function, specifically indicated by the gain-of-function and loss-of-function experiments where Nkx2.7 is observed to regulate the expressions of tbx5 and tbx20 through the heart tube stage.

While Nkx2.5 and Nkx2.7 play redundant roles in cardiac morphogenesis, Nkx2.7 appears to have a more critical function in its effect on cardiac differentiation, as indicated by the gain-of-function and loss-of-function experiments where Nkx2.7 is observed to regulate the expressions of tbx5 and tbx20 through the heart tube stage.

In contrast, no truncating mutations were found in GRIN1, GRIN2A, GRIN2B and GRIN2D genes, suggesting a more critical function of these genes during neurodevelopment and the lethality of the putative loss-of-function.

Although IKKα and IKKβ share considerable sequence identity, it is IKKβ that usually serves the more critical function in the activation of classical NF-κB signalling (Tanaka et al, 1999; Li et al, 1999b, 1999c).

This implies that the extracellular linker may be more important to overall function in HERG, whereas the intracellular linker is more critical for function in KCNQ1.

In contrast, ddb1b-2 modified the majority of det1 adult phenotypes, indicating that in adults DDB1B is more critical for DET1 function than for COP1 function.

Because ddb1b-2 had smaller and no effects on det1 dark and light-grown hypocotyl length, respectively, DDB1B appears to be more critical for COP1 function than for DET1 function with respect to regulation of hypocotyl length.