FISH with a single probe to confirm a suspected diagnosis of a well-described syndrome, such as Williams syndrome, would be a more cost-effective testing methodology.
While the goal of selection and reduction is to produce a more cost-effective test suite, studies presented in the literature show that the techniques may not work effectively, since they discard test cases and consequently, some failures may not be revealed (Jeffrey and Gupta 2007).
If the increasing evidence that IGRA positive subjects have a higher probability of progression to active TB holds true, the IGRA-only screening strategy should prove to be the more cost-effective test.
[ 17] Despite this lower per-test cost for TST, several factors such as differences in test specificity, patient time requirements, and the potential to lower the laboratory cost for IGRA through automation raise the possibility that the IGRA may be the more cost-effective test.
TB becomes more cost effective than dual testing.
The author also correctly points out that large-scale genome-wide approaches are more cost effective than small-scale testing.
We found, for example, in the base case situation that if the utility loss associated with follow-up screenings was the equivalent of seven days of life instead of two days of life per year spent in triage, primary cytological screening with HPV triage would be more cost effective than primary HPV testing.
Our results are consistent with those of Wald et al, 9 who reported that, with a first trimester cut-off point for high risk of 1 in 30, the number of procedure-related euploid miscarriages was greater in contingent and sequential screening options than in the integrated test, and that contingent screening, but not sequential screening, was more cost effective than the integrated test.
12 13 Microscopy is more cost effective than rapid diagnostic tests in settings where there is high throughput.
With these cut-off values, contingent screening remains more cost effective than the integrated test and sequential screening.
(For some less common disorders in this category, preconception screening may be required in order to permit adequate time for follow-up testing or complex laboratory investigations, and to allow for the more cost effective sequential, rather than simultaneous testing).
