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But researchers hope that as more copy number variations are linked to these disorders, such genetic characterizations will become useful tools for predicting the best treatment for a given patient.
Among the strongest associations, we observed outlier expression levels for individuals harboring one or more copy number gains at loci of rare polymorphism (File S1).
The tumors from young patients whom are not carriers of known hereditary CRC syndromes have less gene mutations, but more copy number aberrations across the genome.
Pure DCIS harboured more copy number alterations compared with mixed DCIS.
Thus, any SLE LDG sample that had 18 or more copy number alterations was considered ∆CNVhi.
Metastases (mean: 11.8) showed more copy number changes than local recurrencies (mean: 9.5) and primary tumors (mean: 5.8).
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In stable transfectants, MCRE also enhanced the reporter gene expression at 32°C, although more copy numbers of MCRE were necessary.
We considered polysomy 17 when the cells had three or more copy numbers of centromeres for chromosome 17 per cell.
Interestingly, the semi-cave-dwelling Sr had substantially more copy numbers of immune genes than Sg and Sa (Additional file 2: Table S22), which may be a result of an adaptation to heterogeneous elements between epigean and hypogean habitats, as found in the amphibious mudskippers [ 48].
The dynamics of Xf genome evolution can also be deduced through evaluation of other mobile elements, particularly in the case of GI1, which seems to be absent from the North American strains, but present in one or more copy numbers in South American strains, as shown in Figure 1.
The reason for the discordance with our series (13% versus 50%) could be explained by the consideration of polysomy 17 when the cells had three or more copy numbers of centromeres for chromosome 17 per cell, in agreement with other authors [ 22, 26, 27, 29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com