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The aim of developing oral fluorouracil (5-FU) is to provide a more convenient administration route with similar efficacy and the best achievable tolerance.
Phase 1 and 2 clinical studies with PPX showed encouraging outcomes compared to standard taxanes with reduced neutropenia and alopecia and allowed a more convenient administration schedule without the need for routine premedications.
SC formulations of anti-CD20 mAbs appear to be the next step in development, which could reduce IRRs, eliminate the need for premedication with glucocorticoids, and offer a potentially more convenient administration method.
Patients were willing to accept significant risks of adverse events in return for an increase in the probability of achieving safe platelet levels, to avoid corticosteroids, and for more convenient administration.
A more convenient administration schedule/route, enhanced long-term efficacy and safety profiles, cost-effectiveness, and tolerability, are among the desirable characteristics that future agents must fulfill.
The tocilizumab-SC formulation could provide an additional, more convenient administration option and opportunity for home injection for patients with RA.
Similar(51)
The aim of this study was to investigate the toxicity and efficacy of a more convenient topotecan administration schedule (in contrast to the "standard" 1.5 mg/m2/day × 5 days q 21 days) in the management of platinum- and paclitaxel-refractory ovarian cancer.
These offer potential advantages, including simplification of treatment regimens, more convenient drug administration and reduced healthcare costs [ 5, 9, 10].
Undoubtedly, students offer more convenient survey administration, with relatively large populations in a limited number of locations that are far easier to convene than practicing health workers.
Unlike cytotoxic agents such as intravenous chemotherapy, these targeted treatments may be more appealing in the maintenance setting and thus are generally well tolerated and have a more convenient oral administration for patients.
7 Increasingly, a single-pill combination containing two antihypertensive drugs with complementary mechanisms of action offers potential advantages, including simplification of treatment regimens, more convenient drug administration, increased compliance, and reduced health care costs.
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