For ESR1-positive/HER2-positive tumors the situation is different; HER2 mRNA has a more continuous distribution and the response to neoadjuvant trastuzumab/chemotherapy rises continuously with the amount of HER2 mRNA within the HER2-positive tumor group.
This attractive herb inhabits woodlands of eastern North America and eastern Asia, a common pattern in many plant groups that is thought to represent the remnants of a once more continuous distribution around the north temperate zone.
In contrast, postglacial re-colonisation of acidophilous species in the Scandes might have been less constrained by dispersal limitation because of the more continuous distribution of siliceous bedrocks speeding up the appearance of evolved acidic soils and compensating for the lower total γ-diversity in the Scandes.
The 130 to 430 nt size range DNA had a more continuous distribution, with maximal frequency at 145 nt.
Interestingly, in our study the discordance was higher in ESR1-positive tumors, which might be partially due to the more continuous distribution of HER2 mRNA in this group.
If each neuron contributed a widely different number of synapses to the average, we would have observed a more continuous distribution.
Further, A. germinans showed much higher levels of genetic diversity, especially in plastid genomes, than R. mangle, in spite of the fact that R. mangle populations have a more continuous distribution.
The present-day ecological niche model found the geographic area between these clades unsuitable for either group, but the paleoecological niche model indicated a more continuous distribution across this gap during the Last Glacial Maximum.
Conversely, very few signs of speciation were found in A. inornata, for which populations adopt a much more continuous distribution, and intermediate degrees of speciation and of population structure were found for the third one, S. undulatus.
The lowland areas around Los Tuxtlas today, which include both savannah and wetlands, do not contain any known populations of B. rufescens that would indicate a more continuous distribution in the recent past between these volcanoes and other areas where Nanotriton are found, although more searches would be needed to confirm this.
