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For ESR1-positive/HER2-positive tumors the situation is different; HER2 mRNA has a more continuous distribution and the response to neoadjuvant trastuzumab/chemotherapy rises continuously with the amount of HER2 mRNA within the HER2-positive tumor group.
This was truer for a lower entropy library (average entropy E = 3.29) with four distinct clonal integrations than a higher entropy library (average entropy E = 3.56) with a more continuous distribution of clonality.
This attractive herb inhabits woodlands of eastern North America and eastern Asia, a common pattern in many plant groups that is thought to represent the remnants of a once more continuous distribution around the north temperate zone.
In contrast, postglacial re-colonisation of acidophilous species in the Scandes might have been less constrained by dispersal limitation because of the more continuous distribution of siliceous bedrocks speeding up the appearance of evolved acidic soils and compensating for the lower total γ-diversity in the Scandes.
The 130 to 430 nt size range DNA had a more continuous distribution, with maximal frequency at 145 nt.
Interestingly, in our study the discordance was higher in ESR1-positive tumors, which might be partially due to the more continuous distribution of HER2 mRNA in this group.
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Moreover, the great genetic differentiation among geographically distant populations, determined from the positive value of ΦPT, is in accordance with the theory that the level of genetic heterogeneity among individuals is greater in species with geographically disjunctive populations than in species with more continuous distributions (Hamrick and Godt 1996; Premoli et al. 2001).
Whilst this choice was arbitrary, based on an exploratory rationale, it enabled a more direct comparison with scenario 1 analyses than would have been permitted by fitting a more complex continuous distribution.
We compared the cell orientation based on the 4-unit cell model to the cell model with more continuous receptor distribution on the cell surface (e.g. 36-unit, 72-unit, etc) and we found negligible difference (i.e. less than 0.03%).
If, for practical reasons, models with homogeneous properties within each layer are used, we recommend setting nonzero Kds in the vitric tuffs to mimic the more rigorous continuous distribution simulations.
Endogenous Dsg3 showed a more continuous cell-peripheral distribution than the punctate pattern usually associated with desmosomes as exemplified by Dp staining (Fig. 3A).
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more unequal distribution
more continuous access
more continuous enterprise
more continuous action
more continuous phase
more continuous electron
more continuous area
more scattered distribution
more continuous operation
more continuous energy
more continuous destination-market
more egalitarian distribution
more continuous coverage
more centralized distribution
more continuous experience
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