Sentence examples for more constrained binding from inspiring English sources

The authors also suggest that the more constrained binding modes of the full DPAT agonists and dopamine make them voltage sensitive due to a voltage-induced rotation of TM6 upon receptor activation.

For example, the half-life of a "typical" TFBS is between 10 and 100 Mio years, whereas more constrained binding sites, such as RAREs in mammalian HoxA clusters, have an estimated half-life time of about 150 Mio years.

This indicates that the optimal taxon sampling and phylogenetic depth needed for accurate inferences in binding site density dynamics is variable, such that more constrained sites require deeper taxon sampling, whereas binding site sites with higher turnover rates require dense sampling of younger clades.

Their range of alternatives may be constrained by wartime circumstance — more constrained than Cardona's.

The real situation could probably be more complex, as a duplicate that is not important for the function will tend to be less constrained (some proteins are more constrained than others; environmental proteins may have less constrained sites).

Again, the more constrained one variable is, the less constrained the other is.

The more constrained active site of the I346T mutant displays altered PGH2 substrate analog binding properties.

Conversely, we searched for more constrained genes belonging to 3 functional families : homeobox-domain genes (Hox), odorant and pheromone-binding proteins and immune related genes.

We therefore speculated that binding of IP3 might pull the two domains together in a manner reminiscent of glutamate binding to ionotropic glutamate receptors, and so cause the IBC to adopt a more constrained structure.

The co-planar orientation of GlcN rings in (1↔1) diglucosamine scaffold of DA187 and its confined flexibility would not allow the rearrangement to a more compact conformation wherein the cluster of four C-14 acyl chains would have decreased hydrophobic volume necessary for entering rather constrained binding site of MD-2 (SI Figure 2S).

Things are more constrained today.