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These cell pathways are able to inhibit both angiogenesis and cell proliferation, resulting in more consistent disease control rates and prolongation of progression-free survival (PFS) (Escudier et al, 2013).
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However, we would argue that a slow degenerative phenotype is hard to reconcile with a direct toxic mechanism and that if indeed there were a 'smoking gun' aggregate that was directly neurotoxic, that it would likely show a much better and more consistent correlation with disease or disease progression than do any of the current aggregates.
There are problems of interpretation of Zackrisson's results, notably the relatively recent cessation of screening in one age group, but the results are certainly more consistent with the disease progression modelling which explicitly takes lead time into account (Olsen et al, 2006).
The use of more consistent accounting methods for disease funding, more comprehensive measures of burden and future risk that include impact on health and expenditures, and the timely dissemination of benchmarks on the alignment of disease burden to funding could help to make NIH funding priorities more rationale and transparent.
Even if care should be taken in the context of the low number of TAP-deficient individuals included in this study, our results nevertheless indicate that ILT2 over-expression might be a more consistent finding in this disease than NKG2A over-expression, and that it might be less dependent on the presence of clinical symptoms.
This model simulates PCOS in human beings and is more consistent with the natural disease state.
Many of the best topics are much more consistent with the expected disease terms.
Comparing to results in table 2, the best topics are much more consistent with the expected disease terms.
These values were used to explore the possibility that composite measures might show a more consistent decline through the disease stages.
Interestingly, the fifth patient demonstrated hypometabolism in parietal/precuneus regions with relative sparing of frontal cortical regions, a pattern more consistent with Alzheimer's disease than FTD/ALS.
Based on the results of this study, there is a need for local institutional stakeholders to standardise the activity of veterinary practices in order to have a more effectively coordinated and consistent disease surveillance system.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com