Sentence examples for more conserved sequence from inspiring English sources
Although the differences between high- and low-affinity cre are not very pronounced, the cre boxes with high affinity to CcpA seem to have a more conserved sequence around the middle CpG (conserved GCpGC instead of RCpGY) and at the C13 and A14 positions.
As some of these loci may have been selected for further experiments based on their evolutionary conservation, we note that they are potentially biased toward more conserved sequence.
The promoter peaks are higher than the non-promoter peaks (on average 2.7 times higher, p-value 0.129 on a one-sided Wilcoxon signed-rank test across TFs), and importantly, the promoter peaks have more conserved sequence
The Motif-directed Profiling approach can be applied to any gene family that has multiple members (at least 30 40), and has one or more conserved sequence motif(s) to allow selective binding of a (degenerate) primer to many gene family members.
The mature protein consists of a unique N-terminal domain followed by an alternation of two variable domains and two more conserved sequence domains.
(b) The alignment is informative, if compatible signal-like patterns are based on more conserved sequence positions than contradicting (mutually incompatible) patterns.
On the other hand, these ancient loci have to be detectable across more lineages in order to be included in the older groupings and it is possible that these higher levels of conservation are partly due to an overrepresentation in these groups of more conserved sequences that can be robustly aligned across such a wide phylogenetic range.
To identify the genomic region, two primers (F1, 5′-AAGGCCATGGGGCGTTAGAGCACCGCAGCTAAT-3′ and R1, 5′-ACAGCATATGACCTAGCGGGCGGCCGCGACCCG-3′) were designed on the basis of the more conserved sequences between the alkB gene cluster of different bacteria belonging to the Rhodococcus genus deposited in Genbank DataBase.
This strictness could have biased our data set toward more conserved sequences.
At the C terminus, the alignment showed more conserved sequences and about 80% of proteins passed after the stop codon of Zrg17, with an average of 25 residues.
When we used 50 randomly selected genes (negative control) as input, only one such overrepresented motif was detected (Supplemental File 3), indicating that the meiotically active promoter sequences possess more conserved sequences.
