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The convergence of the process implies that no more conserved interactions can be attained.
Specifically the larger value of GNAS indicates more conserved interactions and higher sequence similarity: (15) GNAS = α × E + 1 − α × ∑ seq u, v.
MacIsaac et al. (2006) used the data provided by Harbison et al. (2004) to construct a regulatory network encompassing different Saccharomyces species, and derived the more conserved interactions.
The conserved graph from PINALOG alignment does not only have more conserved interactions but is also similar in terms of function.
In particular, the results demonstrate that the 3-Opt PISwap can even identify more conserved interactions than were preserved by the initial mapping from GRAAL, which is based purely on network information.
Conversely, functionally similar proteins have more conserved interactions than functionally unrelated genes.
Similar(50)
Beltrao et al. [ 19] observed that stable interactions are more conserved than transient interactions for specific types of interactions (e.g., kinase-substrate interactions determined by phosphoproteomics).
As such, these genes may contain more conserved protein interaction domains and be structurally more "familiar" as interacting partners for the viral proteins and provide ideal candidates for predicting host-pathogen protein interactions.
In the chromatin modeling/remodeling system above, Beltrao et al. (2010) have further noticed that positive interactions are more conserved than negative interactions.
To conclude, while the molecular function of a protein has an effect on the conservation rates of the interactions, we cannot establish a clear trend showing that stable interactions are always more conserved than transient interactions.
We find that interactions between functionally related proteins are more conserved than other interactions.
More suggestions(15)
more complex interactions
more meaningful interactions
more spontaneous interactions
more intimate interactions
more plausible interactions
more indirect interactions
more recent interactions
more positive interactions
more social interactions
more conserved sequences
more conserved regions
more conserved peptides
more romantic interactions
more female interactions
more uncontrolled interactions
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