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Exact(6)
It is expected that HCE genomic location should be more conserved for the comparison between human and rodent than between human and non-mammalian species due to the relatively shorter evolutionary distance.
The variability appears to be functionally more conserved for viral-sensing TLR7 than for the bacterial-sensing TLR.
David Roos (University of Pennsylvania, Philadelphia, USA) showed that protein structure is significantly more conserved for orthologs than for paralogs, particularly within protein active sites.
Interestingly, the minima was found to be even more conserved for the G1- and K2-acetylated protein, suggesting that the bond distance between C18 and C78 was reduced even further.
In addition, the primary structure appears to be more conserved for Nme2a in comparison to Nme2b as they display 73.9 and 67.7% mean aa identities respectively [See Additional file 5].
Consistent with previously reported, similar pattern is also discovered at the genome level, whereas it is more conserved for druggable targets regarding to each subcellular category, and the tendency is more obvious of the low evolution rate in nucleus for druggable targets (fig. 4).
Similar(54)
Although the differences in number are slight, with only 2% more conserved interactions for MP/GA/PATH than for MRF, and 4% more than for IsoRank, this nevertheless confirms that even on this relatively easy optimization problem neither MRF nor IsoRank finds the optimal solution, which can be found by other methods at no additional computational cost.
By contrast, mtDNA sequences of the caeliferans are more conserved, except for sequences of nad2, nad4L, and nad6.
A significant fraction of SLiMs has two or more conserved hydrophobic residues, for instance, the nuclear export sequence (NES) has four [ 44].
The new methods consistently outperform state-of-the-art algorithms, retrieving in particular 78% more conserved interactions than IsoRank for a given level of sequence similarity.
Among DRR proteins, we found that proteins belonging to the nucleotide excision repair pathway were relatively more conserved than proteins needed for the other DRR pathways.
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