The use of a 30% reduction in ADHD symptoms is more conservative than recent trials (25%reductionn; [ 26]) and commensurate with previous work [ 17, 28, 29].
Mean differences (and standard deviations) of this magnitude, and this potential attrition rate are more conservative than a prior intervention trial using these same outcome measures (but evaluating a clinic only based intervention) and our own pilot investigations [ 15, 28].
This may reflect lower power in meta-analyses of randomised controlled trials (due to fewer included studies and participants) and a different range of examined outcomes, or it may in part be due to the more conservative results in randomised controlled trials than in observational studies.
The medical directors also suggested hypotheses that: Norwegian physicians are early adopters of new interventions while the British are more conservative; there are many clinical trials conducted in Norway involving many general practitioners; there is higher cost-awareness among physicians in the UK, in part due to fund holding; and there are publicly funded pharmaceutical advisors in the UK.
Although this trial utilized a more conservative and better-tolerated dose titration protocol than FREEDOM-C or FREEDOM-M, it failed to meet the primary end point, with a +10 m placebo-corrected Hodges Lehmann between-treatment median difference in 6MWD at 16 weeks (P=0.089).
Application of reference intervals derived from populations of different ethnicity and environment might appear to be more conservative, but the primary question of trials in Africa is, and should be, will this investigational product be safe and efficacious in this population?
Over the past decade, consensus guidelines suggested using a more conservative approach based on experimental studies, trials in other populations, and physiologic data [ 6, 7].
Conservative judges get more conservative.
Defense motions to move the trials to Baltimore's more conservative suburbs were denied.
Women with greater church networks and emotional support held more conservative attitudes towards lumpectomy, reconstruction, and clinical trials.
