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However, techniques have been used to account for this bias, resulting in a more conservative summary effect size of 0.21 (95% CI 0.08 to 0.33; p=0.001).
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A full mixed-effect analysis could improve the power of the inference but this is not necessary because we already have significant results using the more conservative summary-statistic approach (Penny and Holmes, 2006).
Some researchers favor not presenting a SOR in the presence of a large amount of unexplained heterogeneity since summary measures generated from random effects models are not always more conservative than summary measures of fixed effect estimates (Higgins et al. 2003; Higgins and Green 2011).
The largest study's result was more conservative than the summary result in 20 (42%) meta-analyses.
Adjustment for publication bias generated a more conservative estimate of summary effect size of 0.21 (0.08 to 0.33).
For these 5 polymorphisms, random effects calculations incorporating between-study heterogeneity revealed more conservative p-values for the summary effects compared with the fixed effects calculations.
A more conservative analysis was based on taking a summary of the trajectory for each patient and comparing those summaries by two-group t-test.
Conservative judges get more conservative.
As can be seen the substantive conclusion is similar but the smaller the within study correlation the more striking the overall summary appears and we have therefore chosen the more conservative value for our presentation.
In summary, TCMCD contains much more complicated structures and its whole molecular scaffolds are more conservative than the commercial libraries.
suggested more conservative clothes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com