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This also reduced the transmission pressure applied by water buffaloes, given the 100∶1 buffalo to human stool weight ratio assumed by the model, resulting in the model making more conservative predictions.
This favors the concept that typically yields the more conservative predictions, such as dose addition.
The score A p, d) was then compared with a specified threshold θ, with higher thresholds yielding more conservative predictions.
The score was then compared with a specified threshold δ with lower thresholds yielding more conservative predictions.
Compared to other prediction systems, Gentrepid is designed to make fewer, more conservative predictions which do not extensively extrapolate existing bioinformatic data i.e. it tends to be more specific than other systems [ 15].
In the ecotoxicologic arena, systematic comparative studies of the mixture effect predictions produced by dose addition and independent action have shown that dose addition yielded the more conservative predictions, but that overall the quantitative differences between both concepts were relatively small (Backhaus et al. 2000; Faust et al. 2003).
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More conservative prediction of real interest rates would be preferable, but in the case of this study, the effect of low interest rate can be normalized since it was applied evenly to all alternatives.
The reason for the difference: The more conservative prediction, made by researchers at the University of Michigan, only takes into account the nutrient-rich agricultural run off from the Mississippi River watershed this spring.
Given the number of correlations, a p value was adjusted (i.e., p < .006) for more conservative prediction [ 30].
However, including these phenotypes should only result in a more conservative prediction of essentiality because it would mean that some of the M. musculus genes might be falsely classed as essential orthologues and when used to predict essentiality in C. elegans would lead to a lower probability of essentiality for C. elegans.
The proposed procedure is also reformulated as a constrained optimization problem to provide more conservative shear predictions.
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