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The TBD-based procedures jointly process more consecutive measurements, thus can increase the signal-to-noise ratio (SNR), and realize the detection and tracking of weak targets simultaneously.
Preeclampsia was defined according to the criteria of the International Society for the Study of Hypertension in Pregnancy [21], as de novo hypertension above 90 mm Hg at two or more consecutive measurements, at least 4 hours apart, and proteinuria above 0.3 g per 24 hours.
Fever was defined as two or more consecutive measurements > 38°C.
All patients had progressive disease as demonstrated by a PSA increase on two or more consecutive measurements taken at least 7 days apart.
Subjects were considered to have progressed to type 2 diabetes if their blood glucose was ≥126 mg/dL under fasting conditions during two or more consecutive measurements and/or ≥200 mg/dL at 2 h after an OGTT.
For three or more consecutive measurements, the slope was calculated between the consecutive viral load measurements using a simple linear regression model [ y = a + bx, where y is the predicted log10 (viral load), a is the intercept, x is the time interval, b is the slope (change in log10 viral load per unit of time)].
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This technique yields more reproducible, consecutive measurements and discloses values probably nearer the real MIP [ 26, 27].
"Prolonged remission" was defined as having two or more consecutive normoglycemic HbA1c measurements, all of which were <5.7%[<399 mmol/mol] over a period of at least 60 months.
"Complete remission" was defined as having two or more consecutive normoglycemic HbA1c measurements, all of which were <5.7%[<399 mmol/mol] over a period of at least 12 months.
For the purposes of the study, virologic failure was defined by two or more consecutive HIV RNA measurements above the detection limit (400cp/ml), 4 – 6 months after the initiation of ART therapy in patients where ≥ 2 viral load measurements were available.
"Partial remission" of diabetes was defined as having two or more consecutive subdiabetic HbA1c measurements, all of which were in the range of 5.7 6.4% [39 46 mmol/mol] over a period of at least 12 months.
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