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We speculate that, eg, the tendency toward reduced adjusted AIS mortality in bisphosphonate users may be due to such a more comprehensive registration of potential confounders.
The supplementation of cancer diagnoses through linkage with cancer registries (Clifford et al, 2005) meant a more comprehensive registration of lung cancer, and the availability of histological and/or cytological confirmation for a majority of cases.
On the other hand, a more comprehensive registration of potential confounders such as osteoporosis and comorbidities among bisphosphonate users vs nonusers may have led us to underestimate mortality associated with bisphosphonates.
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Notification of births aided the latter to an extent, but more comprehensive stillbirth registration was resisted for a further two decades in England, and three in Scotland.
The need for more comprehensive death registration, and the potential contribution of VA in this, is described in a recent blog (1).
Due to the more comprehensive pre-registration training which the pharmacists receive in pharmacology, the research team decided to exclude pharmacists from the current study.
To insure the completeness of registration, more comprehensive solutions involve data linkage of cause of death registers with medical birth registers or birth registration records (Denmark, England and Wales, Finland, Norway and Slovenia), abortion records (Finland) and hospital records (Denmark and Finland).
A more comprehensive data set for registration is currently developed by the Ottawa Group.
The study interval is defined from January 1997 to December 31 , 2008since registration system is more comprehensive after early 1997.
The SMG data set is well known for being more comprehensive than data available from general cancer registration.
As demonstrated by the SmPC language for both cabazitaxel and radium Ra 223 dichloride, the EMA provided more comprehensive coverage of both the positive and negative PRO outcomes from the registration studies for these products, whereas negative PRO outcomes were discussed within the DAP but did not translate into label language in the US.
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