Furthermore, considering both hypogonadal and eugonadal subjects could result in providing a more comprehensive view of physiological effects of testosterone and other androgen endogenous hormones on cardiovascular parameters in CHF patients.
Together with the notion that antibiotics do not only function as weapons against competitors in Nature, but also as signal molecules [34], [35], our results demonstrate that antibiotic resistance genes are more than shields, offering a more comprehensive view of their physiological role in bacterial pathogens.
Future studies will undoubtedly provide a more comprehensive understanding of the physiological functions in the nucleus that are controlled by Ogt and thus help to explain why this enzyme is essential for the viability of mammalian cells.
High spatial and temporal resolution makes this technique very appealing, for both the diagnosis of vascular diseases and in basic neuroscience studies where the aim is to develop a more comprehensive picture of the physiological events accompanying neuronal activation [ 38].
A more comprehensive snapshot of the physiological state may be provided by a metabolic network's reaction flux distribution, which directly reflects the relative engagements of enzymes, integrating the various layers of regulatory processes active in the cell.
Additional measures such as cardiorespiratory and muscle deoxygenation demands might enable a more comprehensive understanding of the acute physiological responses to HIE with COD.
A more comprehensive understanding of the molecular and physiological basis of P uptake, transportation and utilization is leading to formulation of strategies aimed at developing better P efficient cultivars suited for sustainable cropping with less P fertilizer inputs.
This assay can be extended by including temporal gene expression analysis, which can be anchored to these more apical endpoints in order to provide a more comprehensive assessment of the molecular and physiological effects of treatment [ 15, 16].
Experience with this cycle is adapted to the varying constraints imposed by intensive care and becomes more comprehensive as infants progress medically and develop greater physiological stability and behavioral competence.
As CREB/CREM are involved in many physiological and metabolic processes, we used the KEGG pathway function of DAVID annotation (http://david.abcc.ncifcrf.gov/) to make a more comprehensive identification of potential CREB/CREM target genes in physiological functions (see Additional file 9, Table S5).
