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Clearly, MTO brings along numerous further parameters and parameter combinations which can make a more comprehensive multivariate complexity analysis [ 20] very attractive.
Due to the fact that several of these factors most likely are intercorrelated it is important to understand how they relate to WSP in a more comprehensive (multivariate) context when planning for instance prevention, health care and social security systems.
While we interviewed almost all (96%) relevant managers in the selected districts for our study, this nonetheless resulted in a small sample size, that is, the study lacked sufficient power to develop a more comprehensive multivariate model.
Using only univariate analysis to assess the relationship between religion and depression, instead of adopting a more comprehensive multivariate model that controls for potentially intervening covariates, may not accurately reflect the relationship between religion and depression.
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Finally, although our results suggest that the depth of thrombocytopenia was not an accurate predictor of severe bleeding, the retrospective design of the study and the quite low number of patients who bled precluded developing a more comprehensive and reliable multivariate predictive model of bleeding.
A more comprehensive introduction to the multivariate metamodelling methodology is given in Additional file 1: Section S1.
However, until more comprehensive investigations have been performed for the multivariate procedures, it seems prudent to examine the false positive rate in 1,000 permutations of their data before accepting the results at face value.
Although a basic multivariate analysis of our preliminary data does not yet provide high enough sensitivities and specificities (> 70%) for clinically relevant detection and differentiation of all five pathology categories (specifically for benign pathologies), refinement of the measurement technique and multivariate analyses of larger, more comprehensive data sets may improve these capabilities.
The proteomic approach used in the present study combining 2D-DIGE and multivariate modelling provided a more comprehensive comparison of the protein profiles of the human trapezius and vastus lateralis muscle, than previously possible to obtain with immunohistochemistry or SDS-PAGE alone.
Further research may include a more comprehensive evaluation of technology, human and organization issues, in which multivariate analysis can be used to gain insight into the relative contribution of these factors.
Using the 1987 Quebec Health Survey and linking it with fee-for service physician payment data,[ 15] more comprehensive analyses were undertaken to examine the contribution of health services utilization variables in a multivariate model of the recency of mammography use for women aged 50 to 59 years.
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