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Therefore, we may consider TTD as a subset of DrugBank, in which TTD only includes pharmacological targets, and DrugBank includes more comprehensive interaction targets.
This allows InnateDB to expand on linear views of pathways to develop a more comprehensive interaction network perspective, highlighting potential cross-talk between pathways and/or prospective novel pathway members.
To overcome this limitation, molecular features can be mapped into more comprehensive interaction networks, such as protein-protein or protein-DNA interaction networks, which can be much more comprehensive and unbiased, as well as disease and context specific.
A more comprehensive interaction analysis using each of the 10 modes (Additional file 4: Figure S4, A) revealed an extended interaction network of 144 nodes and 234 edges (Additional file 4: Figure S4, B), where the initial 10 nodes are marked in red in the centers of the extended interactions (Additional file 4: Figure S4, B).
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Increasingly, more comprehensive chromatin interaction analyses (3C-seq, 4C, 5C, T2C, Capture-C, and Hi-C) are being used to map looping interactions throughout the genome [ 49, 50, 73, 90– 90].
Although the pathway and GO information provided one of these types of networks, we used a more comprehensive functional interaction database (Reactome FI) [ 16] to obtain functional subgroup networks composed of co-expressed genes induced by helveticoside treatment.
In addition, more various methods could be applied in the field of protein protein interaction predictions to generate more comprehensive interactiome.
There will be greater emphasis on the overlay of binding-site maps of multiple DNA-binding proteins to provide a more comprehensive picture of interactions and complex formation.
Such studies will provide a more comprehensive understanding of the interaction between different epigenetic processes and their biological roles.
To develop a more comprehensive lactation protein-protein interaction network, the scientific literature was mined for genes involved in lactation.
For a more comprehensive understanding of the interaction between the neurites and nanofibers, we also fabricated double-layered scaffolds with uniaxially aligned nanofibers in both top and bottom layers with orthogonal orientations (denoted A/A).
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