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A more comprehensive functional analysis of CD4 T cells producing various combinations of cytokines revealed the presence of a markedly higher frequency of PPD as well as α-crystallin specific 3+ (IFNγ+TNFα+ IL2+) and 2+ (producing any two cytokines) CD4 T cells in R/D vaccinated animals compared to BCG, rBCG and sham immunized animals (Fig. 8B and 8C).
This analysis also showed that RNA-seq and microarray together provide more comprehensive functional information than the individual methods.
Notwithstanding these caveats, the present findings provide a prima facie case for a more comprehensive functional neuroanatomical analysis of emotion processing in the dementias.
Our study provides a more comprehensive functional characterization of the InDels using most of the currently available resources and genomic databases on chicken.
During the last decade, the old paradigm focusing solely on HDL-C levels as predictor of atherosclerosis changed to a more comprehensive, functional view of HDL particles.
Given the improved gene annotation, we could now further refine these data and provide a more comprehensive functional description of the corresponding genes and the respective pathways, while also taking subgenome contributions into account.
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Therefore, more comprehensive epidemiological, functional, and molecular research on the interactions between statins and influenza virus and host immune responses needs to be carried out.
The results obtained clearly show that both definitions of functional links only partially overlap and that APPIA can complement STRING predictions with a more comprehensive definition of functional association between protein pairs.
A more comprehensive analysis using functional markers and species discriminating SNPs could provide more insight into the factors contributing to differential gene flow.
For gene lists derived from tissue-specific expression data, we show that PASTAA yields a more comprehensive number of functional TF tissue associations than alternative methods.
Recent studies [ 26, 27] have focused on looking beyond symptom assessment to a more comprehensive understanding of functional outcomes and the real-world impact of symptom severity and treatment-related improvements [ 27].
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