Global network models allow for more comprehensive and unbiased discovery of therapeutic targets than experimental approaches based on a priori selection of important pathways [16].
While the existing literature has primarily focused on a limited set of candidate promoter regions, epigenome-wide strategies offer a more comprehensive approach for discovery.
With this work we hope to contribute to this effort and to the urgent task of identifying the true nature of the human blood plasma proteome, which holds the potential for more comprehensive diagnostics and crucial biomarker discoveries.
We expect that the RNA-Seq datasets, besides identifying many genes that are affected in expression by Insm1, will serve as a platform for further discoveries, especially as more comprehensive models of the gene regulatory network in endocrine cells are built.
Making the data and related clinical information publicly available will significantly contribute to our understanding of the molecular changes in cancer, enabling new discoveries as well as more comprehensive validation of novel prognostic and predictive signatures.
Thus, to support our hypothesis, further phylogenetic studies, ideally supplemented by the discovery of new fossils, and more comprehensive surveys for living microhylids in Asian areas will be necessary.
In addition, normalization techniques reduce the frequency of highly expressed genes and increase the rate of rare gene discovery [ 13, 14], thus providing more comprehensive coverage of the expressed genome.
As our structural understanding becomes better integrated with ligand-discovery and target gene identification, a more comprehensive picture of their architectural and functional properties will emerge.
This paper integrates previous frameworks that have been used in the behavioral sciences to produce a more comprehensive, specific, and complete framework, consonant with the process of scientific discovery as based on multiple, independent, and converging lines of evidence.
Much more extensive CRM discovery covering a fuller range of intermediate species and a more comprehensive coverage of each locus will be needed to begin addressing these questions something the approach we introduce here will be able to facilitate.
