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Moreover, considering indirect costs, such as overhead and capital, would contribute to a more comprehensive cost estimation for hospital services [28].
We recommend using more comprehensive cost data where possible.
This current approach to molecular diagnosis of NDM provides only a limited sequencing of the known NDM genes and no assessment of possible modifier genetic loci elsewhere in the genome: a more comprehensive cost efficient methodology to scrutinize every new NDM case is necessary.
A more thorough analysis, using more comprehensive cost estimates obtained from a broader perspective indexed using a harmonized European consumer price index for medical consumers may be required to draw firm conclusions regarding European costs.
While the present analysis provides more comprehensive cost estimates, and takes place in an emergency setting with high logistics costs, it is likely that given the equal or greater effect of sprinkles on hemoglobin concentration and anemia prevalence [ 57], that the cost-effectiveness of sprinkles would be greater than that of LNS in averting cases of anemia.
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In order to provide a faster, more comprehensive and cost-effective assay for NSNHL mutations, the HHL APEX (Hereditary Hearing Loss Arrayed Primer Extension) microarray was developed [7].
More controlled studies (replication studies, research based on more comprehensive data, cost-effectiveness studies on CAM for specific diagnostic categories) are indicated.
It was concluded that more controlled studies (replication studies, research based on more comprehensive data, cost-effectiveness studies on CAM for specific diagnostic categories) were indicated.
NGS is beginning to change this, with several commercial laboratories currently offering large panels of NGS-based clinical tests, and more comprehensive and cost-effective testing is on the horizon [ 21].
Microarray-based genomic selection combined with massively parallel high-throughput sequencing is the method of choice to analyze large numbers of genes in a more comprehensive and cost-effective manner.
We also included a more comprehensive list of cost elements than previous cost-effectiveness studies [ 11, 14], which allowed us to analyse the cost components with respect to age and time up to five years.
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