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To better interpret cellular heterogeneity, researchers have developed various high-throughput applications to generate a more comprehensive cellular atlas of the human body.
High content screening generates a more comprehensive cellular phenotype and therefore a more effective way to determine hits.
This multilateral stimulation, likely closer to what inflammatory cells face, favorably elicits a robust and more comprehensive cellular involvement, a suitable situation for the study of anti-inflammatory processes.
In addition, using reliable pathway-based gene interaction data, we constructed a more comprehensive cellular map for OC based on top 100-ranked genes.
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The protective efficacy of replication-competent viral vectors may theoretically be superior to that of replication-incompetent viral vectors, as they might elicit different or more comprehensive innate, cellular, and humoral immune responses.
As almost all aspects of cellular physiology are under control of kinases, we generated more or less comprehensive cellular kinome profiles employing PepChip peptide arrays that contain over 1000 consensus substrates of kinase peptide.
Furthermore, our study reveals that single cell-type profiling provides better resolution of subtle and progressive age-related expression changes (see below), yielding a more comprehensive depiction of cellular aging.
We suggest using GGMs as a standard tool of investigation in future metabolomics studies, utilizing the upcoming wealth of metabolic profiling data to form a more comprehensive picture of cellular metabolism.
Metabolism and calcification genes demonstrated differential expression in addition to immunity genes in A. millepora challenged with bacterial and viral immunogens, providing a more comprehensive picture of cellular events during an acute infection [ 19].
To obtain a more comprehensive understanding of cellular oxidative stress, in addition to staining for pro-oxidant NADPH oxidase p47phox, we stained for the antioxidant enzyme manganese superoxide dismutase (MnSOD) (n = 25).
A more comprehensive understanding of cellular stressors on acute responses and disease pathologies based on the role of energetics and other mitochondrial functions interacting with key pathways will be critical to elucidating their contribution to health outcomes.
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