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More complicated variants have been developed to measure dynamic leg volume changes during exercise or rest.
In many cases we are able to localize the breakpoints of single variants, but in other cases the end-sequence pairs suggest more complicated variants.
While other, more complicated variants of the Rasch model exist, they were not deemed necessary for the purposes of this study.
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Compared to traditional methods, NGS is more effective in revealing possibly causal variants, but counseling patients becomes more complicated due to frequent variants of unknown significance and potentially oligogenic cases.
Simultaneously, non-SNP genomic variants (e.g. polymorphisms at adjacent residues and micro-indels) have more complicated color-space signatures, complicating variation discovery.
Secondly, the findings of the present study argue that the relative abilities of erlotinib/gefitinib-type EGFR TKIs and lapatinib/neratinib TKIs to inhibit different mutationally activated EGFR variants is more complicated than previously thought.
Such sources may include common variants with limited effect size, rare variants with higher effect sizes, structural variations, or even more complicated mechanisms such as epistatic, gene-environment and epigenetic interactions.
To make the situation more complicated, sometimes, a single locus can contain multiple independent risk variants (common or rare).
The existence of unique and new variants specific to particular populations makes the diagnosis more complicated.
I suppose one could argue that it's a privilege to be passable as white, or a variant thereof, but it's a bit more complicated than that.
The effect of gender was robust in realizing all five major variant categories of /dz/, but in a manner more complicated than expected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com