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Tier 2 testing involves long-term assays to establish such interactions, explore more complicated endpoints, and establish dose-response relationships.
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The interpretation of HRQoL MDs can be more complicated than survival endpoints.
However, for low predictable endpoints, such as pCR, OS, EFS (additional file 3), which reflect more complicated clinical outcomes resulting from complex clinical treatments, no explicit molecular mechanisms has been elucidated to date.
More complicated, complex, difficult.
Things have become more complicated.
Nothing more complicated than that".
That has made macroeconomic management more complicated".
The truth is a bit more complicated.
It ain't more complicated than that".
It's no more complicated than that.
The third is a bit more complicated.
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