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As the disease progresses, multiple medications are often prescribed with more complicated dosing schedules and in order to maintain benefit and avoid motor complications, adherence to the prescribed dosing schedule becomes an important issue.
For example, if patients have less contact with medical professionals, they might be less adherent to a more complicated dosing regimen.
Reports of glaucoma adherence studies using medication monitors, have had shorter follow-up time and more complicated dosing regimens than the proposed study [ 63, 64].
Available data at the time for glaucoma adherence studies using medication monitors had shorter follow-up time and more complicated dosing regimens than the proposed study [ 23, 24].
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In other words, it's complicated: more complicated, certainly, than yet another sepia-tinted article of Tory faith: that underachievers and miscreants are best served by an instant dose of the 9-5 grind, whatever their readiness.
Third, many antibiotics can be cleared significantly by RRT, and high-intensity RRT would make it more complicated to adjust the dose of antibiotics and could potentially generate periods of inadequate antibiotic levels, which, in turn, may impede the efficacy of antimicrobial therapy.
Tier 2 testing involves long-term assays to establish such interactions, explore more complicated endpoints, and establish dose-response relationships.
Juweid et al. observed that besides red marrow dose, baseline blood counts, multiple bone and/or marrow metastases and recent chemotherapy are important factors related to haematological toxicity after radio-immunotherapy [ 72], making a dosimetric approach to identify the optimal radionuclide dose more complicated.
It has to be considered that production equipment complexity range from relatively simple instruments, such as dose calibrators, to more complicated devices such as automated systems for radiosynthesis or dispensing.
Therefore, the estimation of Cmax and calculation of volume of distribution after III are more complicated than those after the intravenous bolus dosing.
However, not only the planning of treatment but also the dose delivery technique is more complicated than for three dimensional conformal therapy [ 10].
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