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As a consequence, the kinetics can be probed in a much more sensitive way by supplementing conventional techniques with measurements of the responses to more complex voltage waveforms.
For adaptation currents with more complex voltage dependence, such as a slowly inactivating (mathrm {Na}^) current with fast gating variables, our theory may not apply even in the presence of a SNIC because the scaling argument used to derive Eq. (20) may not be valid even approximately.
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The structure of these additional elements has to be studied in the more complex voltage-gated channels.
Ion transports via junctions however require not only applying DC control voltages, but more complex techniques, because pseudopotential barriers created by RF voltages exist near the center of the junctions.
Due to the fluctuation and unpredictable characteristics of RESs and the system load, the system voltage stability issues become more complex.
Depending on whether the voltage shows simple or more complex spiking, one observes that the interspike interval attains only one value or several different values, respectively.
Some use a single burst of direct current, but most have developed a more complex signal, consisting of a pulse of positive voltage followed by a negative one.
The recent report showed that STIM1 can inhibit L-type voltage-gated Ca2+ channels in neurons [24], indicating that the mechanisms of calcium homeostasis in neurons are more complex than anticipated, and additional links might exist between voltage-dependent Ca2+ channels and SOCE.
Furthermore, since the method is analogous to resistance measurements with a voltage meter in electrical circuits, dynamic Rfluidic measurements were possible in more complex microfluidic designs.
However, the detection of a mutation in the alpha 1-subunit of the voltage sensitive dihydropyridine receptor in a French MH family suggests a more complex pathogenesis of MH [ 9].
The higher-voltage systems will likely include advanced controls, thermal management, and more complex architectures.
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