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Polyadenylation at different sites produces different variants of the 3'UTR, which contributes to a more complex transcriptome [ 46].
DOI: http://dx.doi.org/10.7554/eLife.03523.002 Studies performed over the past decade have unveiled a richer and more complex transcriptome than was previously appreciated (Okazaki et al., 2002; Carninci et al., 2005; Kapranov et al., 2007; Ponjavic et al., 2007).
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Modifications of the original SAGE protocols producing 21 bp tags (LongSAGE; [ 9]) and 26 bp tags (SuperSAGE; [ 10]) have been developed to enable more efficient and unambiguous tag-to-gene assignment in higher organisms with more complex transcriptomes.
In addition, the proteome is orders of magnitude more complex than the transcriptome due to post-translational modifications, protein oxidation or limited protein degradation [ 14].
Kapusta and Feschotte (2014), for instance, suggest that … … species with high TE content and activity, and thus more dynamic genomes, also have more complex and malleable transcriptomes, thereby increasing their capacity to evolve newly functional lncRNA molecules.
(p. 448) … species with high TE content and activity, and thus more dynamic genomes, also have more complex and malleable transcriptomes, thereby increasing their capacity to evolve newly functional lncRNA molecules.
Proteomes are significantly more complex than genomes and transcriptomes due to protein processing and extensive post-translational modification (PTM) of proteins.
As has become apparent recently, the mammalian transcriptome is more complex than previously recognized [ 52- 54].
The data presented here indicate that the retinal transcriptome is more complex than previously understood in at least two ways.
However the eukaryotic transcriptome, and in particular the plant transcriptome, is far more complex than previously believed, alternative splicing and non coding transcripts being amongst the major causes contributing to this complexity.
As we shall show here, the detectable proteome displays distinct differences from the transcriptome, thus suggesting a more complex regulation that was anticipated from the transcriptomic studies.
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