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Exact(6)

Future work should also extend the approach to address crops with more complex trajectories, involving multiple origins and hybridization between populations domesticated in different areas, which would require further methodological development.

Finally, it is important to note, that while we used this method to measure simple movement trajectories in the current study, applying this method to more complex trajectories introduces additional constraints that must be considered.

In contrast, our analysis describes the competition between uphill mutations and more complex trajectories.

Figure 2 in Online Resource 4 shows the same simulation with the previously described more complex trajectories.

The next step will consist in evaluating this approach and extending it to more complex trajectories (metastasis, relapse) and to other cancer localisations.

Finally, we describe how our analysis can be generalized to predict how evolution will choose among even more complex trajectories, such as broad fitness valleys with multiple intermediate genotypes, and we discuss evolution in genotype spaces with many possible evolutionary paths.

Similar(54)

Control models exploit either direct signal-to-articulation mappings, or more complex trajectory formation systems that utilize a phonetic segmentation of the acoustic signal.

Furthermore, this algorithm can be considered to be a universal low-thrust optimizer, and it can easily be used to solve more complex trajectory optimization problems such as multi-swingby problem and multidisciplinary design optimization (MDO) problems.

However, individually beneficial mutations may often compete with more complex evolutionary trajectories.

In this article, we analyze this evolutionary choice between immediately beneficial mutations and more complex mutational trajectories that ultimately lead to higher fitness.

On rugged fitness landscapes where sign epistasis is common, adaptation can often involve either individually beneficial "uphill" mutations or more complex mutational trajectories involving fitness valleys or plateaus.

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