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Some reasons may include if we cannot access the space or if the issue is more complex than initially thought.
As MSC also display neuronal morphologies under appropriate culture conditions, the differentiation capacity of stem cells seems to be more complex than initially thought, but it requires careful characterization of the cells.
The two latter kingdoms were reunited in the century that followed – but the presence of a third dynasty suggests that their fractious relationship and subsequent amalgamation may have been more complex than initially thought.
In 2006, the first archaeological field team began its operations and established that the possible burial sites were more complex than initially thought to be.
Since the introduction of lipidomics, the expanded view of pro-inflammatory and anti-inflammatory contributions of n-3 PUFAs derived eicosanoid/docosanoid signalling is remarkably more complex than initially thought.
These results, together with the motile phenotype displayed by R. typhi [28] confirm that the picture of rickettsial motility is more complex than initially thought.
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This case of HIS trans-differentiation, with tumour cells no longer dependent on BCR signalling, indicates that ibruitinib resistance may be a more complex process than initially thought, and this potent therapy may serve as a strong evolutionary drive to differentiate away from the B-cell identity and its accompanying dependency on BCR signalling.
This proposal has however to be revisited in light of recent experimental data, highlighting a more complex situation than initially thought.
As it happens frequently, diverse experimental evidence has been produced supporting apparently contradictory hypotheses, which may all be partly true but in a wider and more complex context than initially thought.
Many studies have demonstrated that interdigit regression is a more complex process than initially thought [ 5– 17], it includes massive apoptosis, growth arrest, and matrix remodeling of the interdigits [ 18].
The role of ADP emerges as more important and complex than initially thought and may account for some distinguishing features of thrombosis versus haemostasis.
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